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Carbamazepine CAS#298-46-4

Carbamazepine CAS#298-46-4

Basic Information

Carbamazepine
C₁₅H₁₂N₂O
white or pale crystalline powder; white to off-white crystalline powder

Carbamazepine is a white to pale crystalline dibenzazepine compound that is practically insoluble in water. It is used as an active pharmaceutical ingredient in authorized formulations for seizure disorders, trigeminal and glossopharyngeal neuralgia, and selected arrhythmia or diabetes-insipidus applications. Its sodium-channel and GABAA-related pharmacology also supports pharmaceutical analysis and neurological research.

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product description

Chemical Identity: Carbamazepine is a dibenzazepine derivative with CAS#298-46-4 and the molecular formula C₁₅H₁₂N₂O.


Physical Characteristics: The material is typically supplied as a white to off-white crystalline powder and is practically insoluble in water.


Pharmaceutical Raw Material: Carbamazepine is supplied as an active pharmaceutical ingredient for further processing and formulation manufacturing by appropriately authorized facilities.


Quality Specifications: Quality parameters may include identification, assay, related substances, residual solvents, and particle size, according to the applicable grade and agreed specifications.


Product Description of Carbamazepine CAS#298-46-4

Carbamazepine is a white or pale crystalline dibenzazepine antiepileptic agent. It works similarly to phenytoin sodium and is highly effective against psychomotor, generalized and partial seizures.

It shows superior effects on peripheral neuropathy, and is commonly used to relieve trigeminal and glossopharyngeal neuralgia. It is also applicable for arrhythmia and diabetes insipidus with wide clinical uses.

Product Application of Carbamazepine CAS#298-46-4

Carbamazepine is a dibenzazepine antiepileptic with effects similar to phenytoin sodium. It mainly treats psychomotor, generalized and partial seizures, and works better than phenytoin sodium for peripheral neuropathy, trigeminal and glossopharyngeal neuralgia. It is also used for arrhythmia and diabetes insipidus.
Its oral LD50 is 3750 mg/kg in mice and 4025 mg/kg in rats. Pharmacologically, it acts as a sodium channel inhibitor and binds to GABAA receptor benzodiazepine sites for medical and research use.


Product Specifications

Parameters


Melting point191-192 °C (lit.)
Boiling point378.73°C (rough estimate)
density1.1099 (rough estimate)
refractive index1.5906 (estimate)
Fp9℃
storage temp.2-8°C
solubility45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble29mg/mL
formCrystals
pka13.94±0.20(Predicted)
colorAlmost white
Water Solubilitypract. insoluble
Merck141781
BCS Class2
LogP2.45
CAS DataBase Reference298-46-4(CAS DataBase Reference)
NIST Chemistry ReferenceCarbamazepine(298-46-4)
EPA Substance Registry System5H-Dibenz[b,f]azepine-5-carboxamide (298-46-4)


Safety Information


Hazard CodesXn,T,F
Risk Statements42/43-22-20/21/22-39/23/24/25-23/24/25-11
Safety Statements37-24-22-36/37/39-36-45-36/37-16
RIDADRUN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany2
RTECSHN8225000
HS Code29339900
Hazardous Substances Data298-46-4(Hazardous Substances Data)
ToxicityLD50 orally in mice, rats: 3750, 4025 mg/kg (Stenger, Roulet)


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Shipping And Transportation

Delivery Time

Inventory 2-3 working days New manufacturing 7-10 working days

Mode of Transportation
1. By Air, fast but expensive.
2. By Sea, usual and economy.
3. By Train, suit for middle Asia countries.
4. By Express, suit for small package.
We only provide highest quality goods available, accompanied by after support!

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FAQ

1. What products does Shandong Junzheng Chemical supply?
We supply inorganic chemicals, organic solvents, water treatment chemicals, and surfactants, including calcium chloride, soda ash, sodium bicarbonate, caustic soda, citric acid, ethyl acetate, and SLES. Please contact us to confirm specific product availability.


2. Which industries do your products serve?
Our products serve pharmaceutical, agrochemical, dye, rubber, construction, coal processing, and other chemical industries. Product suitability depends on the required grade, specifications, and application.


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Please provide the product name, CAS number, required specifications, quantity, packaging requirements, and destination port. These details help us prepare an accurate quotation.


4. How do you control product quality?
We follow strict quality testing procedures supported by technical personnel, research equipment, and an established management system. Specific quality requirements can be confirmed before placing an order.


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