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Methyl acetoacetate

Methyl acetoacetate

Basic Information

Methyl acetoacetate
MAA

Methyl acetoacetate, often abbreviated MAA, is a versatile organic synthesis reagent with functionality suited to substituted acetoacetate and cyclic compound preparation. It participates in Biginelli chemistry and helps construct pyrazole, pyrimidine, and coumarin derivatives. Other uses include pharmaceutical intermediates, cellulose ether solvents, and amine protection during synthetic sweetener manufacture.

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product description

Versatile Synthetic Reagent: Widely used in pharmaceutical synthesis and various organic reactions.


Key Role in Named Reactions: Participates in the Biginelli reaction, enabling the formation of valuable dihydropyrimidinone compounds.


Broad Derivative Formation: Supports the synthesis of diverse compounds such as pyrazole, pyrimidine, and coumarin derivatives.


Flexible Chemical Functionality: Suitable for producing α-substituted acetoacetic esters and cyclic structures, enhancing application versatility.



Product Description of Methyl acetoacetate CAS#105-45-3

Methyl acetoacetate is a chemical reagent widely used in pharmaceutical synthesis. It participates in the Biginelli reaction, enabling the formation of compounds such as dihydropyrimidinones. In addition, methyl acetoacetate (MAA) is utilized in the preparation of α-substituted acetoacetic esters and various cyclic compounds, including pyrazole, pyrimidine, and coumarin derivatives.


Product Application of Methyl acetoacetate CAS#105-45-3

Methyl acetoacetate (MAA) is used in a variety of applications. It serves as a chemical reagent in organic synthesis and can also function as a solvent for cellulose ethers. It is utilized as an intermediate in the preparation of organic compounds, including the synthesis of nifedipine. In addition, it is applied as a food additive, acting as an amine-protecting agent for synthetic sweeteners. MAA is also used as a pharmaceutical raw material in the production of antibiotics.


Product Specifications

Parameters


Melting point-80 °C (lit.)
Boiling point169-170 °C/70 mmHg (lit.)
density1.076 g/mL at 25 °C (lit.)
vapor density4 (vs air)
vapor pressure1 hPa (20 °C)
refractive indexn20/D 1.419(lit.)
Fp158 °F
storage temp.2-8°C
solubility460 g/L (20°C)
pka10.67±0.46(Predicted)
formLiquid
colorAPHA: ≤20
Odorat 100.00 %. fresh fruity citrus green
PH3.8 (863g/l, H2O, 20℃)
Odor Typefruity
explosive limit1.3-14.2%(V)
Water Solubility460 g/L (20 ºC)
Merck146009
BRN506727
Cosmetics Ingredients FunctionsPERFUMING
InChI1S/C5H8O3/c1-4(6)3-5(7)8-2/h3H2,1-2H3
InChIKeyWRQNANDWMGAFTP-UHFFFAOYSA-N
SMILESCOC(=O)CC(C)=O
LogP0.185 (est)
CAS DataBase Reference105-45-3(CAS DataBase Reference)
NIST Chemistry ReferenceButanoic acid, 3-oxo-, methyl ester(105-45-3)
EPA Substance Registry SystemMethyl acetoacetate (105-45-3)


Safety Information


Hazard CodesXi
Risk Statements36
Safety Statements26
RIDADRNA1993
WGK Germany1
RTECSAK5775000
Autoignition Temperature536 °F
TSCATSCA listed
HazardClassCBL
HS Code29183000
Storage Class10 - Combustible liquids
Hazard ClassificationsEye Dam. 1
Hazardous Substances Data105-45-3(Hazardous Substances Data)
ToxicityLD50 orally in rats: 3.0 g/kg (Smyth, Carpenter)


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Shipping And Transportation

Delivery Time

Inventory 2-3 working days New manufacturing 7-10 working days

Mode of Transportation
1. By Air, fast but expensive.
2. By Sea, usual and economy.
3. By Train, suit for middle Asia countries.
4. By Express, suit for small package.
We only provide highest quality goods available, accompanied by after support!

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FAQ

1. What products does Shandong Junzheng Chemical supply?
We supply inorganic chemicals, organic solvents, water treatment chemicals, and surfactants, including calcium chloride, soda ash, sodium bicarbonate, caustic soda, citric acid, ethyl acetate, and SLES. Please contact us to confirm specific product availability.


2. Which industries do your products serve?
Our products serve pharmaceutical, agrochemical, dye, rubber, construction, coal processing, and other chemical industries. Product suitability depends on the required grade, specifications, and application.


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Please provide the product name, CAS number, required specifications, quantity, packaging requirements, and destination port. These details help us prepare an accurate quotation.


4. How do you control product quality?
We follow strict quality testing procedures supported by technical personnel, research equipment, and an established management system. Specific quality requirements can be confirmed before placing an order.


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