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Isoniazid CAS#54-85-3

Isoniazid CAS#54-85-3

Basic Information

Isoniazid
c; o; l; o; r; l; e; s; s; ; o; r; ; w; h; i; t; e; ; c; r; y; s; t; a; l; l; i; n; e; ; p; o; w; d; e; r

Isoniazid is a colorless to white crystalline compound with water solubility and chemically reactive hydrazine functionality. It participates in condensation with carbonyl compounds to produce Schiff bases and related derivatives. Besides pharmaceutical intermediate applications, it is used in electroplating additives and analytical luminescence systems, including reactions studied with gold nanoparticle-catalyzed luminol chemistry.

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product description

Excellent Stability and Water Solubility: Isoniazid is chemically stable and readily soluble in water, supporting convenient formulation and broad application use.


Strong Reducing Properties: The hydrazine group provides excellent reducing capability, enabling reactions such as the conversion of dissolved oxygen to hydrogen peroxide under alkaline conditions.


Versatile Chemical Reactivity: Its active amino group (-NH₂) allows efficient reactions with carbonyl compounds, carboxylic acid derivatives, and sulfonyl chlorides, making it a valuable intermediate for derivative synthesis.


Suitable for Analytical and Luminescent Systems: It can participate in gold nanoparticle-catalyzed luminol luminescent systems, offering potential advantages in analytical and detection applications.


Product Description of Isoniazid CAS#54-85-3

Isoniazid is colorless or white crystalline powder with slight bitterness, stable and easily soluble in water.

Its hydrazine group has strong reducibility, capable of reducing dissolved oxygen under alkaline conditions for luminescent analysis use. Its amino group enables reactions to synthesize Schiff bases and various isoniazid derivatives.


Product Application of Isoniazid CAS#54-85-3

Isoniazid is a first-line, affordable anti-tuberculosis drug with high efficacy and low toxicity, also used as electroplating additive and chemical intermediate.
It can undergo condensation reactions to form multiple derivatives with anti-tuberculosis effects. Isoniazid shows the strongest potency, while its hydrazone has weaker antibacterial action yet lower neuro and hepatic toxicity.
It features strong selective inhibition against tubercle bacilli, achieving bacteriostasis at low concentrations and sterilization at higher doses for clinical and research use.
Product Specifications

Parameters


Melting point171-173 °C (lit.)
Boiling point251.97°C (rough estimate)
density1.2620 (rough estimate)
bulk density800kg/m3
refractive index1.6910 (estimate)
Fp>250°C
storage temp.2-8°C
solubility125g/l
formCrystals or Crystalline Powder
pkapKa 2.00/3.60/10.8(H2O) (Uncertain)
colorWhite or colorless
PH6-8 (50g/l, H2O, 20℃)
OdorOdorless
PH Range5.5 - 6.5 at 10 g/l at 25 °C
Water Solubility14 g/100 mL (25 ºC)
SensitiveAir Sensitive
Merck145186
BRN119374
BCS Class1,3
Stability:Stability Stable, but may be air or light sensitive. Combustible. Incompatible with strong oxidizing agents, chloral, aldehydes, iodine, ferric salts, hypochlorites.
InChIKeyQRXWMOHMRWLFEY-UHFFFAOYSA-N
CAS DataBase Reference54-85-3(CAS DataBase Reference)
NIST Chemistry ReferenceIsoniazid(54-85-3)
IARC3 (Vol. 4, Sup 7) 1987
EPA Substance Registry SystemIsoniazid (54-85-3)


Safety Information


Hazard CodesXn
Risk Statements22-38-40-36/37/38
Safety Statements37-36/37/39-26
RIDADR2811
WGK Germany3
RTECSNS1751850
TSCAYes
PackingGroupIII
HS Code29333999
Hazardous Substances Data54-85-3(Hazardous Substances Data)
ToxicityLD50 in mice (mg/kg): 151 i.p., 149 i.v. (Jenney, Pfeiffer)


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Shipping And Transportation

Delivery Time

Inventory 2-3 working days New manufacturing 7-10 working days

Mode of Transportation
1. By Air, fast but expensive.
2. By Sea, usual and economy.
3. By Train, suit for middle Asia countries.
4. By Express, suit for small package.
We only provide highest quality goods available, accompanied by after support!

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FAQ

1. What products does Shandong Junzheng Chemical supply?
We supply inorganic chemicals, organic solvents, water treatment chemicals, and surfactants, including calcium chloride, soda ash, sodium bicarbonate, caustic soda, citric acid, ethyl acetate, and SLES. Please contact us to confirm specific product availability.


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Our products serve pharmaceutical, agrochemical, dye, rubber, construction, coal processing, and other chemical industries. Product suitability depends on the required grade, specifications, and application.


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