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Paclitaxel CAS#33069-62-4

Paclitaxel CAS#33069-62-4

Basic Information

Paclitaxel

Paclitaxel is a diterpene obtained from yew bark and used in pharmaceutical applications and cell-division studies. Its biochemical interactions involve binding to polymerized microtubules and influencing their assembly and persistence. This microtubule-associated behavior distinguishes its laboratory role, while the supplied material does not provide an appearance, solvent profile or specific commercial form for the product.

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product description

Paclitaxel promotes microtubule polymerization and stabilizes polymerized microtubules, a unique mechanism among known drugs.


It specifically binds to polymerized microtubules without affecting unpolymerized tubulin dimers.


Paclitaxel interferes with cellular functions by causing microtubule accumulation, effectively blocking cell division during mitosis.


Clinically effective for ovarian and breast cancer, with additional therapeutic effects on lung cancer, colorectal cancer, melanoma, head and neck cancer, lymphoma, and brain tumors.



Product Description of Paclitaxel CAS#33069-62-4

Paclitaxel is a diterpene extracted from yew bark. It uniquely promotes and stabilizes microtubule polymerization, binding only to formed microtubules. It disrupts cell division and arrests mitosis. Clinically, it is mainly used for ovarian and breast cancers, and also effective against lung, colorectal, melanoma, lymphoma and other malignancies.


Product Application of Paclitaxel CAS#33069-62-4

Paclitaxel is a natural broad-spectrum anticancer drug mainly for metastatic breast and ovarian cancers. It binds β-tubulin to stabilize microtubules, block depolymerization and arrest cell cycle at G2/M phase to suppress mitosis. It also acts effectively on human endothelial cells with low IC50 value.

Product Specifications

Parameters


Melting point213 °C (dec.)(lit.)
alphaD20 -49° (methanol)
Boiling point774.66°C (rough estimate)
density0.2
refractive index-49 ° (C=1, MeOH)
Fp9℃
storage temp.2-8°C
solubilitymethanol: 50 mg/mL, clear, colorless
formpowder
pka11.90±0.20(Predicted)
colorwhite
Water Solubility0.3mg/L(37 ºC)
λmax227nm(MeOH)(lit.)
Merck146982
BRN1420457
Stability:Stable. Incompatible with strong oxidizing agents. Combustible.
InChIKeyRCINICONZNJXQF-MZXODVADSA-N
LogP3.950 (est)
CAS DataBase Reference33069-62-4(CAS DataBase Reference)
EPA Substance Registry SystemPaclitaxel (33069-62-4)


Safety Information


Hazard CodesXn
Risk Statements37/38-41-42/43-62-68-40-48-20/21/22-68/20/21/22
Safety Statements22-26-36/37/39-45
RIDADR1544
WGK Germany3
RTECSDA8340700
F45951
HazardClass6.1(b)
PackingGroupIII
HS Code29329990
Hazardous Substances Data33069-62-4(Hazardous Substances Data)
ToxicityLD50 intraperitoneal in mouse: 128mg/kg
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Shipping And Transportation

Delivery Time

Inventory 2-3 working days New manufacturing 7-10 working days

Mode of Transportation
1. By Air, fast but expensive.
2. By Sea, usual and economy.
3. By Train, suit for middle Asia countries.
4. By Express, suit for small package.
We only provide highest quality goods available, accompanied by after support!

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1. What products does Shandong Junzheng Chemical supply?
We supply inorganic chemicals, organic solvents, water treatment chemicals, and surfactants, including calcium chloride, soda ash, sodium bicarbonate, caustic soda, citric acid, ethyl acetate, and SLES. Please contact us to confirm specific product availability.


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Our products serve pharmaceutical, agrochemical, dye, rubber, construction, coal processing, and other chemical industries. Product suitability depends on the required grade, specifications, and application.


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